产品货号：
GS4658
中文名称：
重组人IL-36β(157a.a.)
英文名称：
Recombinant Human Interleukin-36 beta, 157a.a.
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.7kDa,a single non-glycosylated polypeptide chain containing 157 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin.Furthermore,it can stimulate production of interleukin-6 and interleukin-8 in synovial fibroblasts,articular chondrocytes and mature adipocytes.Two alternatively spliced transcript variants encode distinct(164 or 157 residues)protein isoforms that differ in their C-terminal 70 amino acid residues have been reported and IL-36β isoform 2 is synthesized as a 157 a.a.protein.Specifically,human IL-36β shares low sequence identity with IL-1β,IL-36RA,IL-36α and IL-36γ.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-36β(157a.a.)，IL-36β, 157a.a., Human，Recombinant Human Interleukin-36 beta, 157a.a.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin.Furthermore,it can stimulate production of interleukin-6 and interleukin-8 in synovial fibroblasts,articular chondrocytes and mature adipocytes.Two alternatively spliced transcript variants encode distinct(164 or 157 residues)protein isoforms that differ in their C-terminal 70 amino acid residues have been reported and IL-36β isoform 2 is synthesized as a 157 a.a.protein.Specifically,human IL-36β shares low sequence identity with IL-1β,IL-36RA,IL-36α and IL-36γ.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The specific activity is determined by its binding ability in a functional ELISA.Immobilized rHuIL-36β at 1μg/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 μg/mL. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIL-36β,157a.a.as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE |
相关搜索：重组人IL-36β(157a.a.)，IL-36β, 157a.a., Human，Recombinant Human Interleukin-36 beta, 157a.a.